Recapitulating T cell infiltration in 3D psoriatic skin models for patient-specific drug testing
نویسندگان
چکیده
منابع مشابه
A 3D-psoriatic skin model for dermatological testing: The impact of culture conditions
BACKGROUND Inadequate representation of the human tissue environment during a preclinical screen can result in inaccurate predictions of compound effects. Consequently, pharmaceutical investigators are searching for preclinical models that closely resemble original tissue for predicting clinical outcomes. METHODS The current research aims to compare the impact of using serum-free medium inste...
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Background and aim: Adult T cell leukemia/lymphoma (ATLL) is an aggresive malignancy which may occur in human T lymphotropic virus1(HTLV1) infected persons. HTLV1 is endemic in Khorasan with prevalence of 2.3% in general population. Since specific cutaneous manifestations of lymphoma may occur in a significant number of patients, we studied ATLL patients in Mashhad.Mate...
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A utogenous ear reconstruction remains one of the formidable procedures in plastic surgery. Precise 3-dimensional (3D) sculpting of the auricular construct is central to an operation, which requires countless patient experiences to hone one's surgical skill. Current methods to autogenous ear construction entail tracing the contra-lateral (unaffected) ear, if available, and using this 2D outline...
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INTRODUCTION: Smoking has been associated with increased wound healing complications and overall morbidity in multiple specialties, including plastic surgery.1 From 2005–2014, the smoking rate among U.S. adults decreased from 20.9% to 16.8%.2 This study aims to investigate first, whether smoking prevalence in the plastic surgery patient population paralleled the declining national trend and sec...
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In the ordinary linear models, regressing the residuals against lagged values has been suggested as an approach to test the hypothesis of zero autocorrelation among residuals. In this paper we extend these results to the both equally and unequally replicated functionally measurement error models. We consider the equally and unequally replicated cases separately, because in the first case the re...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-60275-0